Klopp’s side require a draw to ensure their qualification for the knockout stages after suffering defeat against Napoli at Anfield last month.
Salzburg have been one of the most exciting sides in this year’s competition and pushed Liverpool all the way in the reverse fixture, overcoming a three-goal deficit before Mohamed Salah struck the eventual winner.
In the unlikely event that Genk defeat Napoli, though, Liverpool will qualify regardless of the result.
Here is everything you need to know about the game:
What time is kick-off?
The match starts at 17.55 on Tuesday 10 December.
How can I watch it?
The match will be broadcast live on BT Sport 3 and the BT Sport app.
RB Salzburg: Stankovic; Kristensen, Onguene, Wober, Ulmer; Mwepu, Junuzovic, Szoboszlai, Minamino; Daka, Haaland
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Lallana, Henderson, Wijnaldum; Salah, Firmino, Mane
Dejan Lovren is likely to miss out after picking up an injury during Saturday’s victory against Bournemouth, although Georginio Wijnaldum and Adam Lallana are expected to be available having missed out. Fabinho and Joel Matip remain long-term absentees.
Seydou Koita, Patrick Farkas and Antoine Bernede have been ruled out, although Salzburg’s goalkeeper Cican Stankovic should be available after recovering from a thigh injury.