The two Premier League rivals meet in the last-eight with the visitors set to look a lot different to the side currently 10 points clear in the Premier League.
With Jurgen Klopp and his first-team squad in Qatar on Club World Cup duty Under-23s coach Neil Critchley is set to take charge of a very young side at Villa Park.
They will be looking to spring an upset against Villa with a place in the last four up for grabs.
Here’s everything you need to know:
When is the game?
The match takes place on Tuesday night with kick-off at Villa Park at 7.45pm.
How can I watch it?
The match is being broadcast on Sky Sports Football, Sky Sports Main Event and Sky Sports Ultra HD.
It can also be streamed online on desktop or mobile devices via the SkyGo app.
Villa are set to make changes with several of Dean Smith’s fringe players likely to get a chance to push their cases for more first-team football.
For the visitors, Curtis Jones and Neco Williams were set to feature but both have been called up to head to Qatar with the senior squad.
Whoever starts it is likely to be the youngest team in Liverpool’s history.
Liverpool: Kelleher; Hoever, Van den Berg, Koumetio, Larouci, Christie-Davies, Kane, Chirivella, Longstaff, Elliott, Brewster
Aston Villa: Nyland, Elmohamady, Hause, Konsa, Taylor, Luiz, Lansbury, Hourihane, Jota, Trezeguet, Kodija
The young Reds are undoubtedly talented but they will have it all to do against what even with wholesale changes will be a vastly more experienced home team. Aston Villa 3-1 Liverpool